{"id":83570,"date":"2022-01-04T16:46:03","date_gmt":"2022-01-04T16:46:03","guid":{"rendered":"http:\/\/wordpress.gurbuz.net\/?p=83570"},"modified":"2022-01-04T16:54:41","modified_gmt":"2022-01-04T16:54:41","slug":"ailede-ilk-omikron-kadincagiz-birkac-ay-oence-koronaya-yakalanmisti-bu-sefer-omikron-alman-haberlerinde-duen-duen-tayyipistan-omikron-hakim","status":"publish","type":"post","link":"http:\/\/wordpress.gurbuz.net\/?p=83570","title":{"rendered":"Ailede ILK Omikron, kad\u0131nca\u011f\u0131z birka\u00e7 ay \u00f6nce Koronaya yakalanm\u0131\u015ft\u0131. Bu sefer Omikron. Alman haberlerinde d\u00fcn, d\u00fcn Tayyipistan, Omikron HAKIM"},"content":{"rendered":"<blockquote class=\"twitter-tweet\" data-width=\"525\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\">2) The mutations have caused \u201cFourteen amino acid substitutions, and 9 amino acid deletions\u2014which are located in the spike protein.\u201d <a href=\"https:\/\/t.co\/7HP8HmnaYi\">https:\/\/t.co\/7HP8HmnaYi<\/a><\/p>\n<p>&mdash; Eric Feigl-Ding (@DrEricDing) <a href=\"https:\/\/twitter.com\/DrEricDing\/status\/1478100263185657856?ref_src=twsrc%5Etfw\">January 3, 2022<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p>&#8222;Emergence in Southern France of a new SARS-CoV-2 variant of probably Cameroonian origin harbouring both substitutions N501Y and E484K in the spike protein<br \/>\nPhilippe Colson, J\u00e9r\u00e9my Delerce, Emilie Burel, Jordan Dahan, Agn\u00e8s Jouffret, Florence Fenollar, Nouara Yahi, Jacques Fantini, Bernard La Scola, Didier Raoult<br \/>\ndoi: https:\/\/doi.org\/10.1101\/2021.12.24.21268174<br \/>\nThis article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.<br \/>\nAbstractFull TextInfo\/HistoryMetrics Preview PDF<br \/>\nABSTRACT<br \/>\nSARS-CoV-2 variants have become a major virological, epidemiological and clinical concern, particularly with regard to the risk of escape from vaccine-induced immunity. Here we describe the emergence of a new variant. For twelve SARS-CoV-positive patients living in the same geographical area of southeastern France, qPCR testing that screen for variant-associated mutations showed an atypical combination. The index case returned from a travel in Cameroon. The genomes were obtained by next-generation sequencing with Oxford Nanopore Technologies on GridION instruments within \u22488 h. Their analysis revealed 46 mutations and 37 deletions resulting in 30 amino acid substitutions and 12 deletions. Fourteen amino acid substitutions, including N501Y and E484K, and 9 deletions are located in the spike protein. This genotype pattern led to create a new Pangolin lineage named B.1.640.2, which is a phylogenetic sister group to the old B.1.640 lineage renamed B.1.640.1. Both lineages differ by 25 nucleotide substitutions and 33 deletions. The mutation set and phylogenetic position of the genomes obtained here indicate based on our previous definition a new variant we named \u201cIHU\u201d. These data are another example of the unpredictability of the emergence of SARS-CoV-2 variants, and of their introduction in a given geographical area from abroad.<\/p>\n<p>Competing Interest Statement<br \/>\nDR has a conflict of interest being a consultant for Hitachi High-Technologies Corporation, Tokyo, Japan from 2018 to 2020. All other authors have no conflicts of interest to declare. Funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.<\/p>\n<p>Funding Statement<br \/>\nThis work was supported by the French Government under the Investments for the Future program managed by the National Agency for Research (ANR), no. Mediterranee-Infection 10-IAHU-03 Region Provence Alpes Cote d Azur and European funding FEDER PRIMMI (Fonds Europeen de Developpement Regional-Plateformes de Recherche et d Innovation Mutualisees Mediterranee Infection), no. FEDER PA 0000320 PRIMMI Hitachi High-Technologies Corporation, Tokyo, Japan.&#8220;<\/p>\n<p>https:\/\/www.medrxiv.org\/content\/10.1101\/2021.12.24.21268174v1<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2) The mutations have caused \u201cFourteen amino acid substitutions, and 9 amino acid deletions\u2014which are located in the spike protein.\u201d https:\/\/t.co\/7HP8HmnaYi &mdash; Eric Feigl-Ding (@DrEricDing) January 3, 2022 &#8222;Emergence in Southern France of a new SARS-CoV-2 variant of probably Cameroonian origin harbouring both substitutions N501Y and E484K in the spike protein Philippe Colson, J\u00e9r\u00e9my Delerce, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"http:\/\/wordpress.gurbuz.net\/?p=83570\" class=\"more-link\"><span class=\"screen-reader-text\">\u201eAilede ILK Omikron, kad\u0131nca\u011f\u0131z birka\u00e7 ay \u00f6nce Koronaya yakalanm\u0131\u015ft\u0131. Bu sefer Omikron. Alman haberlerinde d\u00fcn, d\u00fcn Tayyipistan, Omikron HAKIM\u201c<\/span> weiterlesen<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=\/wp\/v2\/posts\/83570"}],"collection":[{"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=83570"}],"version-history":[{"count":5,"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=\/wp\/v2\/posts\/83570\/revisions"}],"predecessor-version":[{"id":83577,"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=\/wp\/v2\/posts\/83570\/revisions\/83577"}],"wp:attachment":[{"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=83570"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=83570"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/wordpress.gurbuz.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=83570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}