{"id":103514,"date":"2022-08-12T11:31:08","date_gmt":"2022-08-12T11:31:08","guid":{"rendered":"http:\/\/wordpress.gurbuz.net\/?p=103514"},"modified":"2022-08-12T13:45:20","modified_gmt":"2022-08-12T13:45:20","slug":"centaurus-ba-2-75","status":"publish","type":"post","link":"http:\/\/wordpress.gurbuz.net\/?p=103514","title":{"rendered":"Centaurus, BA. 2.75"},"content":{"rendered":"

Cogito, ergo sum<\/strong>
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„NEWS
\n10 August 2022
\nWill \u2018Centaurus\u2019 be the next global coronavirus variant? Indian cases offers clues
\nThe BA.2.75 variant is rising fast in the country, but hospitalization rates are low so far.<\/p>\n

As countries await the end of COVID-19 surges caused by the variant BA.5, researchers are on the lookout for what will come next.<\/p>\n

An Omicron subvariant called BA.2.75 \u2014 and nicknamed \u2018Centaurus\u2019 by some on social media \u2014 is rising fast in India. A few scientists are sounding the alarm, whereas others say it\u2019s too early to tell whether the variant will spread widely. In India, it doesn\u2019t yet seem to be driving up hospitalization or death rates.<\/p>\n

BA.2.75 has been detected in more than 20 countries worldwide, and researchers are waiting to learn whether it will substantially elevate case numbers after a wave of infections with BA.5.<\/p>\n

A slew of studies suggests that the two variants have roughly similar capacities to dodge immunity conferred by infection and vaccination. This suggests that \u2018Centaurus\u2019 might not push cases much higher outside India \u2014 at least not while population immunity is high and before the variant picks up many extra mutations.<\/p>\n

On the alert
\nSurveillance of SARS-CoV-2 variants is falling by the wayside in many countries, but India seems to be at the epicentre of the spread of BA.2.75. This mutation-laden lineage evolved from the BA.2 subvariant of Omicron, which spread widely in early 2022 (see \u2018Pathogen progression\u2019).<\/p>\n

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Researchers in India have sequenced more than 1,000 samples of the variant since May. The data suggest that about two-thirds of new cases there are currently caused by BA.2.75, says Shahid Jameel, a virologist at the University of Oxford, UK, who previously led India\u2019s SARS-CoV-2 sequencing consortium (see \u2018\u2018Centaurus\u2019 grows\u2019).<\/p>\n

The variant seems to have a \u201cquite sizeable\u201d transmission advantage over BA.5 in India, says Tom Wenseleers, an evolutionary biologist at the Catholic University of Leuven in Belgium, who has modelled its rise. \u201cThis would definitely cause an infection wave,\u201d he says. The number of confirmed infections \u2014 a sliver of the probable true number \u2014 is up across India, Wenseleers notes, as is the percentage of tests that come back positive (a more reliable measure when testing rates are low).<\/p>\n

So far, BA.2.75 has been detected at relatively low rates outside India, in countries including Japan, the United States and the United Kingdom, which are in the middle of or just past the peaks of surges caused mainly by BA.5.<\/p>\n

As a result, Jameel does not expect BA.2.75 to trigger big waves in most places. \u201cWe\u2019re coming to a point where these variants are sort of competing with each other and they\u2019re almost equivalent,\u201d he says. \u201cI think people who have had BA.5 will not have a breakthrough infections with BA.2.75, and vice versa.\u201d<\/p>\n

Neck and neck
\nLaboratory studies posted on preprint servers in recent weeks lend credence to this idea1\u20135. Several teams have found that the two variants have a similar ability to evade antibodies triggered by vaccination and previous infection, with BA.5 showing a slight edge over its distant cousin. This makes BA.2.75\u2019s rise in India \u2014 where BA.5 is also present \u2014 fairly perplexing, says Yunlong Richard Cao, an immunologist at Peking University in Beijing who co-led one of the studies1. \u201cIt\u2019s weird.\u201d<\/p>\n

His team thinks that India\u2019s immunity profile is part of the explanation. In 2021, the country saw an explosive wave of cases caused by the Delta variant, which shares a key mutation with BA.5. Cao suspects that previous Delta infections provide added protection against BA.5, leaving an opening for BA.2.75.<\/p>\n

Cao and his team found that several people who had had Delta infections after vaccination produced antibodies that were more potent against BA.5 than against BA.2.75. \u201cMy guess is that BA.2.75 probably won\u2019t prevail that much outside India\u201d, especially in countries that weren\u2019t hit hard by Delta, Cao adds.<\/p>\n

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Other researchers say the small number of Delta infections after vaccination in Cao and his colleagues\u2019 study means the hypothesis should be treated with caution. Moreover, Wenseleers has found tentative signs that BA.2.75 might be spreading a little faster than BA.5 in some countries, including Australia, the United Kingdom, the United States and Canada.<\/p>\n

He predicts that BA.2.75 will continue to grow globally, particularly in Asia and Oceania. But there are also signs that another Omicron sub-lineage that’s growing in Europe and North America, called BA.4.6, is just as transmissible as BA.2.75. „We might end up with an eclectic mix of Omicron descendants, with different ones reaching dominance in different parts of the world,“ Wenseleers says.<\/p>\n

No hospitalization surge
\nSo far, India isn\u2019t seeing a significant rise in hospitalizations from its \u2018Centaurus\u2019 wave, says Jameel, who gives credit to the combined effects of high rates of vaccination and of previous infection. \u201cThis hybrid immunity is going to largely protect and keep people out of hospitals,\u201d he adds.<\/p>\n

Wenseleers and others expect the same pattern to be repeated elsewhere \u2014 whether the next variant is BA.2.75 or something else entirely. \u201cHigher and higher population immunity leads to less and less severe consequences for most people,\u201d he says.<\/p>\n

If BA.2.75 doesn\u2019t spread widely now, it could in several months\u2019 time, as it picks up new immune-evading mutations and protection caused by BA.5 infection wanes, says Cao. Some BA.2.75 sequences include a mutation found in BA.5, called L452R, that could augment the variant\u2019s ability to reinfect people, he adds. \u201cThis is what makes it scary.\u201d<\/p>\n

Even if hospitalization and death rates stay low in a wave caused by Centaurus or whatever comes next, researchers say, the high frequency of infection waves could mean more long COVID and general disruption caused by high levels of illness. \u201cThe next thing we need to do is bring down infection volumes,\u201d says Wenseleers. \u201cAt the end of the day, that\u2019s the problem.\u201d<\/p>\n

doi: https:\/\/doi.org\/10.1038\/d41586-022-02154-4<\/p>\n

References
\nCao, Y. et al. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.07.18.500332 (2022).<\/p>\n

Sheward, D. J. et al. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.07.19.500716 (2022).<\/p>\n

Wang, Q. et al. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.07.31.502235 (2022).<\/p>\n

Wang, X. et al. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.08.04.502716 (2022).<\/p>\n

Saito, A. et al. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.08.07.503115 (2022).“<\/p>\n

https:\/\/www.nature.com<\/strong>\/articles\/d41586-022-02154-4<\/p>\n

China, Russia…
\nIran, India…
\nI am on your side.<\/strong><\/p>\n

*<\/p>\n

Algoritmen…
\nHigh-frequency-trading…
\nFucked the World…
\nBut…
\nI…
\nNot yet!<\/p>\n

„In einer Fabrikhalle wenige Kilometer \u00f6stlich von London steht ein riesiger Computer<\/strong>, der dar\u00fcber bestimmt, wie gef\u00e4hrlich der „Islamische Staat“ ist. Wie viel Macht der amerikanische Pr\u00e4sident Barack Obama besitzt. Wie lange Venezuela noch zahlungsf\u00e4hig ist. 11.02.2016″<\/p>\n

https:\/\/www.zeit.de\/2016\/07\/oel-preis-verbilligung-macht-gewinner-verlierer#:~:text=In%20einer%20Fabrikhalle%20wenige%20Kilometer,lange%20Venezuela%20noch%20zahlungsf%C3%A4hig%20ist.<\/p>\n

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Bitte lesen<\/a><\/p>\n

Weder…
\nWo ich auf die Welt kam noch wo ich satt werde…
\nWeder land noch Leute…
\nAber…
\nAMerika aber Engl\u00e4nder es IST erst der Anfang<\/p>\n

*<\/p>\n

„DER SPIEGEL<\/p>\n

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https:\/\/www.msn.com\/de-de\/finanzen\/top-stories\/w%C3%A4rmepumpen-und-solaranlagen-hohe-kosten-schrecken-vor-kauf-ab\/ar-AA10ABag?ocid=msedgntp&cvid=b5f9342e015b429ae0020c79e5b7014c<\/p>\n